Exploring the association between a cholecystokinin promoter polymorphism (rs1799923) and posttraumatic stress disorder in combat veterans.

ABSTRACT:

Background

Cholecystokinin (CCK) is a neuropeptide that has been implicated in understanding the acquisition and extinction of fear. Research on CCK in anxiety has primarily focused on understanding panic attacks and panic disorder. Emerging data suggests that CCK may also hold promise in understanding the development and maintenance of posttraumatic stress disorder (PTSD).

Method

The present study examined whether a single nucleotide polymorphism in the promoter region of the CCK gene (C>T; rs1799923) was associated with an increased prevalence of PTSD as well as with severity of PTSD symptoms among a sample of 457 combat veterans.

Results

Results demonstrated that participants with either the heterozygous or homozygous T allele had an increased prevalence of PTSD re

SUBMITTER: Badour CL 

PROVIDER: S-EPMC6545578 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature