A dual controllability analysis of influenza virus-host protein-protein interaction networks for antiviral drug target discovery.

ABSTRACT:

Background

Host factors of influenza virus replication are often found in key topological positions within protein-protein interaction networks. This work explores how protein states can be manipulated through controllability analysis: the determination of the minimum manipulation needed to drive the cell system to any desired state. Here, we complete a two-part controllability analysis of two protein networks: a host network representing the healthy cell state and an influenza A virus-host network representing the infected cell state. In this context, controllability analyses aim to identify key regulating host factors of the infected cell's progression. This knowledge can be utilized in further biological analysis to understand disease dynamics and isolate proteins for study as d

SUBMITTER: Ackerman EE 

PROVIDER: S-EPMC6545738 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature