Highly Selective Fluorescent Probe for the Detection of Copper (II) and Its Application in Live Cell Imaging.

ABSTRACT: The development of fluorescent methods for the detection of metal ions is of great importance due to their diverse environmental and biological roles. Herein, a rhodamine 6G-based off-on fluorescent probe (L1) with a t-butyl pyrrole moiety as the recognition site was designed and synthesized. Photophysical studies show that L1 exhibits excellent sensitivity and selectivity towards Cu²⁺ to other metal ions in neutral acetonitrile aqueous media. Mechanism studies suggest that the recognition process may associate with a Cu²⁺ promoted hydrolysis reaction of L1. Furthermore, L1 has been successfully applied in fluorescence imaging of Cu²⁺ ion in living cells.

SUBMITTER: Guo Z 

PROVIDER: S-EPMC6545799 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature