A seven-year study on the effect of the pre-erythrocytic malaria vaccine candidate RTS,S/AS01 _E on blood stage immunity in young Kenyan children.

ABSTRACT: Background: RTS,S/AS01 _E, the most advanced malaria vaccine confers partial immunity. The vaccine-induced pre-erythrocytic immunity reduces exposure to blood-stage parasites, delaying acquisition of antibodies to blood-stage antigens.  However, the duration of this effect is unknown. Methods: We measured, by enzyme-linked immunosorbent assay, IgG-antibodies to 4 Plasmodium falciparum blood-stage antigens (AMA1, MSP1 ₄₂, EBA175, and MSP3) on 314 children randomized to receive RTS,S/AS01 _E or Rabies vaccine at 5 - 17 months of age in a phase 2b trial in Kenya, and thereafter participated in a 7-year study of the duration of vaccine immunity. Results: Antibody levels to MSP1 ₄₂, AMA1 and EBA175 were slightly lower among t

SUBMITTER: Ndungu FM 

PROVIDER: S-EPMC6545824 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature