CD150^high CD4 T cells and CD150^high regulatory T cells regulate hematopoietic stem cell quiescence via CD73.

ABSTRACT: Various extrinsic signals tightly control hematopoietic stem cell quiescence. Our recent study showed that hematopoietic stem cells are regulated by a special FoxP3⁺ regulatory T-cell population with high expression of a hematopoietic stem cell marker, CD150. Extracellular adenosine generated via a cell-surface ectoenzyme CD39 on CD150^high regulatory T cells maintained hematopoietic stem cell quiescence. It remains unclear how conventional T cells and the other cell-surface ectoenzyme, CD73, contribute to regulation of hematopoietic stem cells. This work shows that CD150^high regulatory T cells as well as unique CD150^high CD4⁺ conventional T cells regulate hematopoietic stem cells via CD73. Global CD73 deletion increased the numbers of

SUBMITTER: Hirata Y 

PROVIDER: S-EPMC6545860 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature