Therapeutic effect of Anakinra in the relapsing chronic phase of febrile infection-related epilepsy syndrome.

ABSTRACT: Febrile infection-related epilepsy syndrome (FIRES) is a severe epileptic encephalopathy with presumed inflammatory origin and lacking effective treatments. Anakinra is the human recombinant interleukin 1 receptor antagonist clinically used in autoinflammatory or autoimmune conditions. We report a case of FIRES for which the spatial and temporal match between electroencephalography (EEG) and magnetic resonance imaging (MRI) focal alterations provides support for the detrimental synergic interplay between seizures and inflammation that may evolve to permanent focal lesions and progressive brain atrophy in weeks to months. Brain biopsy showed aspects of chronic neuroinflammation with scarce parenchymal lymphocytes. We report the novel evidence that anakinra reduces the relapse of highly recu

SUBMITTER: Dilena R 

PROVIDER: S-EPMC6546072 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature