Liver-related events and mortality among elderly patients with advanced chronic hepatitis C treated with direct-acting antivirals.

ABSTRACT:

Background

Direct-acting antivirals (DAAs) are effective in patients aged ≥65 years. However, little is known about the effects of DAAs on survival, liver decompensation and development of hepatocellular carcinoma (HCC).

Objective

To compare the incidence of liver-related events and mortality between patients aged ≥65 and <65 years.

Methods

Prospective study comparing patients aged ≥65 and <65 years treated with DAAs. The incidence of liver-related events and mortality, and HCC was compared between age groups.

Results

Five hundred patients (120 aged ≥65 and 380 aged <65 years) were included. The incidence of liver-related events was 2.62 per 100 patient-years (py) in older and 1.41/100 py in younger patients. All-cause mortality was 3.89 and 1.27/100 py in olde

SUBMITTER: Rodriguez-Osorio I 

PROVIDER: S-EPMC6546209 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature