Challenges and caveats of a multi-center retrospective radiomics study: an example of early treatment response assessment for NSCLC patients using FDG-PET/CT radiomics.

ABSTRACT:

Background

Prognostic models based on individual patient characteristics can improve treatment decisions and outcome in the future. In many (radiomic) studies, small size and heterogeneity of datasets is a challenge that often limits performance and potential clinical applicability of these models. The current study is example of a retrospective multi-centric study with challenges and caveats. To highlight common issues and emphasize potential pitfalls, we aimed for an extensive analysis of these multi-center pre-treatment datasets, with an additional 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) scan acquired during treatment.

Methods

The dataset consisted of 138 stage II-IV non-small cell lung cancer (NSCLC) patients from four diffe

SUBMITTER: van Timmeren JE 

PROVIDER: S-EPMC6546238 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature