Host contact dynamics shapes richness and dominance of pathogen strains.

ABSTRACT: The interaction among multiple microbial strains affects the spread of infectious diseases and the efficacy of interventions. Genomic tools have made it increasingly easy to observe pathogenic strains diversity, but the best interpretation of such diversity has remained difficult because of relationships with host and environmental factors. Here, we focus on host-to-host contact behavior and study how it changes populations of pathogens in a minimal model of multi-strain interaction. We simulated a population of identical strains competing by mutual exclusion and spreading on a dynamical network of hosts according to a stochastic susceptible-infectious-susceptible model. We computed ecological indicators of diversity and dominance in strain populations for a collection of networks illustra

SUBMITTER: Pinotti F 

PROVIDER: S-EPMC6546247 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature