Randomization in survival studies: An evaluation method that takes into account selection and chronological bias.

ABSTRACT: The random allocation of patients to treatments is a crucial step in the design and conduct of a randomized controlled trial. For this purpose, a variety of randomization procedures is available. In the case of imperfect blinding, the extent to which a randomization procedure forces balanced group sizes throughout the allocation process affects the predictability of allocations. As a result, some randomization procedures perform superior with respect to selection bias, whereas others are less susceptible to chronological bias. The choice of a suitable randomization procedure therefore depends on the expected risk for selection and chronological bias within the particular study in question. To enable a sound comparison of different randomization procedures, we introduce a model for the comb

SUBMITTER: Ruckbeil MV 

PROVIDER: S-EPMC6546249 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature