Enhanced cell functions on graphene oxide incorporated 3D printed polycaprolactone scaffolds.

ABSTRACT: For tissue engineering applications, a porous scaffold with an interconnected network is essential to facilitate the cell attachment and proliferation in a three dimensional (3D) structure. This study aimed to fabricate the scaffolds by an extrusion-based 3D printer using a blend of polycaprolactone (PCL), and graphene oxide (GO) as a favorable platform for bone tissue engineering. The mechanical properties, morphology, biocompatibility, and biological activities such as cell proliferation and differentiation were studied concerning the two different pore sizes; 400 μm, and 800 μm, and also with two different GO content; 0.1% (w/w) and 0.5% (w/w). The compressive strength of the scaffolds was not significantly changed due to the small amount of GO, but, as expected scaffolds with 400 μm po

SUBMITTER: Unagolla JM 

PROVIDER: S-EPMC6546300 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature