Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway.

ABSTRACT:

Background

Patients with chronic kidney disease (CKD) and coincident heart failure with preserved ejection fraction (HFpEF) may constitute a distinct HFpEF phenotype. Osteopontin (OPN) is a biomarker of HFpEF and predictive of disease outcome. We recently reported that OPN blockade reversed hypertension, mitochondrial dysfunction, and kidney failure in Col4a3^-/- mice, a model of human Alport syndrome.

Objectives

The purpose of this study was to identify potential OPN targets in biopsies of HF patients, healthy control subjects, and human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs), and to characterize the cardiac phenotype of Col4a3^-/- mice, relate this to HFpEF, and investigate possible causative roles for OPN in driving the cardiom

SUBMITTER: Yousefi K 

PROVIDER: S-EPMC6546303 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature