Intestinal luminal putrescine is produced by collective biosynthetic pathways of the commensal microbiome.

ABSTRACT: The intestinal microbiome produces various metabolites that may harm or benefit the host. However, the production pathways of these metabolites have not been well characterised. The polyamines putrescine and spermidine required for physiological process are also produced by intestinal microbiome. The production and release of these polyamines by microbiome are poorly understood, though we have confirmed that intestinal bacteria produced putrescine from arginine. In this study, we characterised polyamine synthesis by analysing the collective metabolic functions of the intestinal microbiome. In particular, we analysed polyamines and their intermediates in faecal cultures, as well as the colonic contents of rats injected with isotope-labelled arginine through a colon catheter, using mass spec

SUBMITTER: Nakamura A 

PROVIDER: S-EPMC6546329 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature