Cardiac Fibrotic Remodeling on a Chip with Dynamic Mechanical Stimulation.

ABSTRACT: Cardiac tissue is characterized by being dynamic and contractile, imparting the important role of biomechanical cues in the regulation of normal physiological activity or pathological remodeling. However, the dynamic mechanical tension ability also varies due to extracellular matrix remodeling in fibrosis, accompanied with the phenotypic transition from cardiac fibroblasts (CFs) to myofibroblasts. It is hypothesized that the dynamic mechanical tension ability regulates cardiac phenotypic transition within fibrosis in a strain-mediated manner. In this study, a microdevice that is able to simultaneously and accurately mimic the biomechanical properties of the cardiac physiological and pathological microenvironment is developed. The microdevice can apply cyclic compressions with gradient magn

SUBMITTER: Kong M 

PROVIDER: S-EPMC6546425 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature