Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage.

ABSTRACT: The lung is a specialized barrier organ that must tightly regulate interstitial fluid clearance and prevent infection in order to maintain effective gas exchange. Lymphatic vessels are important for these functions in other organs, but their roles in the lung have not been fully defined. In the present study, we addressed how the lymphatic vasculature participates in lung homeostasis. Studies using mice carrying a lymphatic reporter allele revealeded that, in contrast to other organs, lung lymphatic collecting vessels lack smooth muscle cells entirely, suggesting that forward lymph flow is highly dependent on movement and changes in pressure associated with respiration. Functional studies using CLEC2-deficient mice in which lymph flow is impaired due to loss of lympho-venous hemostasis or

SUBMITTER: Reed HO 

PROVIDER: S-EPMC6546450 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature