Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.

ABSTRACT:

Background

The "atopic march" has been considered a linear progression starting with eczema and culminating with development of asthma. Not all asthma cases, however, are preceded by eczema, and not all children with eczema go on to develop asthma.

Objective

The aim of this study was to explore the impact of allergic sensitization patterns on the association between early eczema and later childhood asthma. Given the numerous reported associations of the ciliary gene KIF3A with the atopic march, we also examined the impact of KIF3A risk allele rs12186803 on our analyses.

Methods

We studied 505 participants in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), a prospective birth cohort, with longitudinal eczema and asthma outcomes as well as prospective

SUBMITTER: Johansson E 

PROVIDER: S-EPMC6546546 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature