Supramolecular peptide constructed by molecular Lego allowing programmable self-assembly for photodynamic therapy.

ABSTRACT: Peptide self-assemblies with multiple nanostructures have great potentials in functional biomaterials, and yet the tedious and costly covalent peptide modification and the lack of facile controllability on self-assembly morphology retard the peptide-related exploration. Here we report a simple approach to fabricate a supramolecular peptide that shows programmable self-assembly with multiple morphologies and application in photodynamic therapy. Pillar[5]arene-based host-guest recognition is used to construct a supramolecular peptide, which simplify the peptide modification and promote the controllability of the self-assembly behavior. Due to the ERGDS sequences on the exterior surfaces and hydrophobic cores of self-assemblies, the nanoparticles formed from the supramolecular peptide are sui

SUBMITTER: Zhu H 

PROVIDER: S-EPMC6546686 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature