Ontology highlight
ABSTRACT:
SUBMITTER: Hashimoto S
PROVIDER: S-EPMC6546774 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Nature communications 20190603 1
To understand the molecular processes that link Aβ amyloidosis, tauopathy and neurodegeneration, we screened for tau-interacting proteins by immunoprecipitation/LC-MS. We identified the carboxy-terminal PDZ ligand of nNOS (CAPON) as a novel tau-binding protein. CAPON is an adaptor protein of neuronal nitric oxide synthase (nNOS), and activated by the N-methyl-D-aspartate receptor. We observed accumulation of CAPON in the hippocampal pyramidal cell layer in the App<sup>NL-G-F</sup> -knock-in (KI) ...[more]