Is Experimental Evolution of an Increased Aerobic Exercise Performance in Bank Voles Mediated by Endocannabinoid Signaling Pathway?

ABSTRACT: The level of physical activity achieved in a given situation depends on both physiological abilities and behavioral characteristics (motivation). We used a unique animal model to test a hypothesis that evolution of an increased aerobic exercise performance can be facilitated by evolution of motivation to undertake physical activity, mediated by brain endocannabinoid system. Bank voles (Myodes glareolus) from "aerobic" A lines selected for 22 generations for high swim-induced aerobic metabolism (VO₂swim) achieved 65% higher "voluntary maximum" VO₂swim than voles from unselected, "control" C lines. In C lines, VO₂swim was 24% lower than the maximum forced-running aerobic metabolism (VO₂run), while in A lines VO₂swim and VO_2</

SUBMITTER: Jaromin E 

PROVIDER: S-EPMC6546880 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature