Characterization of the Metabolic Fate of Datura metel Seed Extract and Its Main Constituents in Rats.

ABSTRACT: Datura metel L. has been frequently used in Chinese traditional medicine. However, little is known on the chemical composition and in vivo metabolism of its seeds. In this study, using the strategy "chemical analysis, metabolism of single representative compounds, and metabolism of extract at clinical dosage" that we propose here, 42 constituents were characterized from D. metel seeds water extract. Furthermore, the metabolic pathways of 13 representative bioactive compounds of D. metel seeds were studied in rats after the oral administration of D. metel seeds water extract at a clinical dosage (0.15 g/kg). These included three withanolides, two withanolide glucosides, four amides, one indole, one triterpenoid, one steroid, and one sesquiterpenoid, and wi

SUBMITTER: Xia C 

PROVIDER: S-EPMC6546908 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature