Role of forward and reverse signaling in Eph receptor and ephrin mediated cell segregation.

ABSTRACT: Eph receptor and ephrin signaling has a major role in segregating distinct cell populations to form sharp borders. Expression of interacting Ephs and ephrins typically occurs in complementary regions, such that polarised activation of both components occurs at the interface. Forward signaling through Eph receptors can drive cell segregation, but it is unclear whether reverse signaling through ephrins can also contribute. We have tested the role of reverse signaling, and of polarised versus non-polarised activation, in assays in which contact repulsion drives cell segregation and border sharpening. We find that polarised forward signaling drives stronger segregation than polarised reverse signaling. Nevertheless, reverse signaling contributes since bidirectional Eph and ephrin activation dr

SUBMITTER: Wu Z 

PROVIDER: S-EPMC6546932 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature