Abnormal blood lactate accumulation during repeated exercise testing in myalgic encephalomyelitis/chronic fatigue syndrome.

ABSTRACT: Post-exertional malaise and delayed recovery are hallmark symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Studies on repeated cardiopulmonary exercise testing (CPET) show that previous exercise negatively affects oxygen uptake (VO₂ ) and power output (PO) in ME/CFS. Whether this affects arterial lactate concentrations ([La_a ]) is unknown. We studied 18 female patients (18-50 years) fulfilling the Canadian Consensus Criteria for ME/CFS and 15 healthy females (18-50 years) who underwent repeated CPETs 24 h apart (CPET₁ and CPET₂ ) with [La_a ] measured every 30th second. VO₂ at peak exercise (VO_2peak ) was lower in patients than in controls on CPET₁ (P < 0.001) and decreased in pat

SUBMITTER: Lien K 

PROVIDER: S-EPMC6546966 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature