Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment.

ABSTRACT:

Objective

It is unclear whether the decline in dopamine transporters (DAT) differs among idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with different levels of olfactory impairment. This study aimed to characterize DAT changes in relation to nonmotor features in iRBD patients by olfactory loss.

Methods

This prospective cohort study consisted of three age-matched groups: 30 polysomnography-confirmed iRBD patients, 30 drug-naïve Parkinson's disease patients, and 19 healthy controls without olfactory impairment. The iRBD group was divided into two groups based on olfactory testing results. Participants were evaluated for reported prodromal markers and then underwent 18F-FP-CIT positron emission tomography and 3T MRI. Tracer uptakes were analyzed in the c

SUBMITTER: Lee JY 

PROVIDER: S-EPMC6547034 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature