Duration of Immunity and Effectiveness of Diphtheria-Tetanus-Acellular Pertussis Vaccines in Children.

ABSTRACT:

Importance

The United States has experienced a nationwide resurgence of pertussis since the mid-1970s, despite high estimated vaccine coverage. Short-lived immunity induced by diphtheria-tetanus-acellular pertussis (DTaP) vaccines in young children is widely believed to be responsible for this growing burden, but the duration of protection conferred by DTaP vaccines remains incompletely quantified.

Objective

To assess the duration of immunity and the effectiveness of DTaP vaccines in US children.

Design, setting, and participants

A mathematical, age-structured model of pertussis transmission, previously validated empirically on incidence data in Massachusetts, was used in this simulation study to assess the duration of DTaP immunity most consistent with the empirical

SUBMITTER: Domenech de Celles M 

PROVIDER: S-EPMC6547082 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature