Association of Preoperative Renin-Angiotensin System Inhibitors With Prevention of Postoperative Atrial Fibrillation and Adverse Events: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Postoperative atrial fibrillation (POAF) is a well-known complication after cardiac surgery. Renin-angiotensin system inhibitors (RASIs) have been suggested as an upstream therapy for selected patients with AF; however, evidence in the surgical setting is limited.

Objective

To evaluate the role of preoperative RASIs in prevention of POAF and adverse events for patients undergoing cardiac surgery.

Data sources

The PubMed database and the Cochrane Library from inception until December 31, 2018, were searched by using the keywords renin-angiotensin system inhibitors OR angiotensin-converting enzyme inhibitors OR angiotensin receptor blocker OR aldosterone antagonist AND cardiac surgery. ClinicalTrials.gov was searched from inception until December 31, 2018, by

SUBMITTER: Chen S 

PROVIDER: S-EPMC6547087 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature