Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding.

ABSTRACT:

Importance

Triptans, the most efficient acute treatment for migraine attacks, are 5-HT1B/1D receptor agonists, but their precise mechanism of action is not completely understood. The extent to which triptans enter the central nervous system and bind to 5-HT1B receptors in the brain is unknown.

Objectives

To determine the occupancy of sumatriptan to central 5-HT1B receptors, and to investigate changes in brain serotonin levels during migraine attacks.

Design, setting, and participants

This study of 8 patients in Denmark used a within-participant design and was conducted from April 20, 2015, to December 5, 2016. Participants were otherwise healthy patients with untreated episodic migraine without aura, aged between 18 and 65 years, and recruited from the general communi

SUBMITTER: Deen M 

PROVIDER: S-EPMC6547094 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature