Association of Early-Onset Alzheimer Disease With Elevated Low-Density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB.

ABSTRACT:

Importance

Early-onset Alzheimer disease (EOAD) is a rare form of Alzheimer disease (AD) with a large genetic basis that is only partially understood. In late-onset AD, elevated circulating cholesterol levels increase AD risk even after adjusting for the apolipoprotein E ε4 (APOE E4) allele, a major genetic factor for AD and elevated cholesterol levels; however, the role of circulating cholesterol levels in EOAD is unclear.

Objectives

To investigate the association between circulating cholesterol levels and EOAD and to identify genetic variants underlying this possible association.

Design, setting, and participants

In this case series, plasma cholesterol levels were directly measured in 267 samples from the AD research centers (ADRCs) of Emory University and Universit

SUBMITTER: Wingo TS 

PROVIDER: S-EPMC6547122 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature