Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration.

ABSTRACT:

Importance

Age-related macular degeneration (AMD) is a common threat to vision loss in individuals older than 50 years. While neovascular complications in AMD are treatable, there is currently no therapy for geographic atrophy secondary to AMD. Geographic atrophy lesion progression over time shows considerable interindividual variability, but little is known about prognostic factors.

Objective

To elucidate the contribution of common genetic variants to geographic atrophy lesion growth.

Design, setting, and participants

This pooled analysis combined 4 independent studies: the Fundus Autofluorescence Imaging in Age-Related Macular Degeneration (FAM) study, the Directional Spread in Geographic Atrophy (DSGA) study, the Age-Related Eye Disease Study (AREDS), and the Geogr

SUBMITTER: Grassmann F 

PROVIDER: S-EPMC6547131 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature