Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study.

ABSTRACT:

Importance

Positron emission tomography (PET) imaging now allows in vivo visualization of both neuropathologic hallmarks of Alzheimer disease (AD): amyloid-β (Aβ) plaques and tau neurofibrillary tangles. Observing their progressive accumulation in the brains of clinically normal older adults is critically important to understand the pathophysiologic cascade leading to AD and to inform the choice of outcome measures in prevention trials.

Objective

To assess the associations among Aβ, tau, and cognition, measured during different observation periods for 7 years.

Design, setting, and participants

Prospective cohort study conducted between 2010 and 2017 at the Harvard Aging Brain Study, Boston, Massachusetts. The study enrolled 279 clinically normal participants. An addit

SUBMITTER: Hanseeuw BJ 

PROVIDER: S-EPMC6547132 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature