Role of Adjuvant Multimodality Therapy After Curative-Intent Resection of Ampullary Carcinoma.

ABSTRACT:

Importance

Ampullary adenocarcinoma is a rare malignant neoplasm that arises within the duodenal ampullary complex. The role of adjuvant therapy (AT) in the treatment of ampullary adenocarcinoma has not been clearly defined.

Objective

To determine if long-term survival after curative-intent resection of ampullary adenocarcinoma may be improved by selection of patients for AT directed by histologic subtype.

Design, setting, and participants

This multinational, retrospective cohort study was conducted at 12 institutions from April 1, 2000, to July 31, 2017, among 357 patients with resected, nonmetastatic ampullary adenocarcinoma receiving surgery alone or AT. Cox proportional hazards regression was used to identify covariates associated with overall survival. The surger

SUBMITTER: Ecker BL 

PROVIDER: S-EPMC6547142 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature