Evaluation of Differences in Individual Treatment Response in Schizophrenia Spectrum Disorders: A Meta-analysis.

ABSTRACT:

Importance

An assumption among clinicians and researchers is that patients with schizophrenia vary considerably in their response to antipsychotic drugs in randomized clinical trials (RCTs).

Objective

To evaluate the overall variation in individual treatment response from random variation by comparing the variability between treatment and control groups.

Data sources

Cochrane Schizophrenia, MEDLINE/PubMed, Embase, PsycINFO, Cochrane CENTRAL, BIOSIS Previews, ClinicalTrials.gov, and World Health Organization International Clinical Trials Registry Platform from January 1, 1955, to December 31, 2016.

Study selection

Double-blind, placebo-controlled, RCTs of adults with a diagnosis of schizophrenia spectrum disorders and prescription for licensed antipsychotic drug

SUBMITTER: Winkelbeiner S 

PROVIDER: S-EPMC6547253 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature