Global serum proteomic changes in water buffaloes infected with Fasciola gigantica.

ABSTRACT:

Background

The liver fluke Fasciola gigantica modulates several signaling pathways in infected buffaloes to facilitate its survival and establishment of persistent infection. In response to the parasite invasion, buffaloes activate innate and adaptive immune responses to counter the parasite infection. To detect new proteins that might be involved in the interaction between F. gigantica and the buffaloes, and that also might serve as biomarkers for fasciolosis, we used proteomic techniques to study the serum proteome of buffaloes during F. gigantica infection. Here, we used an isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomic approach to identify serum proteins that are differentially expressed in infected buffaloes compared to uninfected con

SUBMITTER: Zhang FK 

PROVIDER: S-EPMC6547537 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature