Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia.

ABSTRACT:

Background

Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously showed that nitric oxide synthase 2 (NOS2) is required, but not sufficient, for the effect of endotoxin on HPV. The aim of the current study was to identify additional factors that might contribute to the impairment of HPV during endotoxemia.

Methods

Gene expression profiling was determined using pulmonary tissues from NOS2-deficient (NOS2^-/-) and wild-type mice subjected to endotoxin or saline challenge (control). HPV was accessed as the percentage increase in left pulmonary vascular resistance (LPVR) in response to left main bronchus occlusion (L

SUBMITTER: Petersen B 

PROVIDER: S-EPMC6547543 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature