Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors.

ABSTRACT: Increasing evidence supports that cellular dysregulations in the degradative routes contribute to the initiation and progression of neurodegenerative diseases, including Alzheimer's disease. Autophagy and endolysosomal homeostasis need to be maintained throughout life as they are major cellular mechanisms involved in both the production of toxic amyloid peptides and the clearance of misfolded or aggregated proteins. As such, alterations in endolysosomal and autophagic flux, as a measure of degradation activity in these routes or compartments, may directly impact as well on disease-related mechanisms such as amyloid-β clearance through the blood-brain-barrier and the interneuronal spreading of amyloid-β and/or Tau seeds, affecting synaptic function, plasticity and metabolism. The emerging o

SUBMITTER: Van Acker ZP 

PROVIDER: S-EPMC6547588 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature