Gene expression and promoter methylation of angiogenic and lymphangiogenic factors as prognostic markers in melanoma.

ABSTRACT: The high mortality rate of melanoma is broadly associated with its metastatic potential. Tumor cell dissemination is strictly dependent on vascularization; therefore, angiogenesis and lymphangiogenesis play an essential role in metastasis. Hence, a better understanding of the players of tumor vascularization and establishing them as new molecular biomarkers might help to overcome the poor prognosis of melanoma patients. Here, we further characterized a linear murine model of melanoma progression and showed that the aggressiveness of melanoma cells is closely associated with high expression of angiogenic factors, such as Vegfc, Angpt2, and Six1, and that blockade of the vascular endothelial growth factor pathway by the inhibitor axitinib abrogates their tumorigenic potential in vitro and in

SUBMITTER: Monteiro AC 

PROVIDER: S-EPMC6547615 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature