Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood-brain barrier penetration.

ABSTRACT: Gold nanoparticles (AuNPs) have been extensively used as nanomaterials for theranostic applications due to their multifunctional characteristics in therapeutics, imaging, and surface modification. In this study, the unique functionalities of exosome-derived membranes were combined with synthetic AuNPs for targeted delivery to brain cells. Here, we report the surface modification of AuNPs with brain-targeted exosomes derived from genetically engineered mammalian cells by using the mechanical method or extrusion to create these novel nanomaterials. The unique targeting properties of the AuNPs after fabrication with the brain-targeted exosomes was demonstrated by their binding to brain cells under laminar flow conditions as well as their enhanced transport across the blood brain barrier. In a

SUBMITTER: Khongkow M 

PROVIDER: S-EPMC6547645 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature