Validation of a prediction algorithm for progression to advanced macular degeneration subtypes.

ABSTRACT:

Importance

Risk score models predicting the progression of age-related macular degeneration (AMD) to its advanced forms may be useful for targeting high-risk individuals for lifestyle changes that reduce risk for AMD progression, helping with differential diagnosis of AMD and its subtypes, identifying high-risk subjects for participation in clinical trials, and selecting appropriate therapies.

Objective

To develop and validate a predictive model for progression to advanced stages of AMD in 2 independent cohorts. DESIGN Participants in a validation cohort and an independent derivation population were classified into 5 stages of AMD based on ocular examination and fundus photographs at baseline. Progression was defined as either eye progressing from stage 1, 2, or 3 to either

SUBMITTER: Seddon JM 

PROVIDER: S-EPMC6547827 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature