Heterogenising study samples across testing time improves reproducibility of behavioural data.

ABSTRACT: The ongoing debate on the reproducibility crisis in the life sciences highlights the need for a rethinking of current methodologies. Since the trend towards ever more standardised experiments is at risk of causing highly idiosyncratic results, an alternative approach has been suggested to improve the robustness of findings, particularly from animal experiments. This concept, referred to as "systematic heterogenisation", postulates increased external validity and hence, improved reproducibility by introducing variation systematically into a single experiment. However, the implementation of this concept in practice requires the identification of suitable heterogenisation factors. Here we show that the time of day at which experiments are conducted has a significant impact on the reproducibil

SUBMITTER: Bodden C 

PROVIDER: S-EPMC6547843 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature