T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33.

ABSTRACT: Perinatal T cells broadly access nonlymphoid tissues, where they are exposed to sessile tissue antigens. To probe the outcome of such encounters, we examined the defective elimination of self-reactive clones in Aire-deficient mice. Nonlymphoid tissues were sequentially seeded by distinct waves of CD4⁺ T cells. Early arrivers were mostly Foxp3⁺ regulatory T (T reg) cells and metabolically active, highly proliferative conventional T cells (T conv cells). T conv cells had unusually high expression of PD-1 and the IL-33 receptor ST2. As T conv cells accumulated in the tissue, they gradually lost expression of ST2, ceased to proliferate, and acquired an anergic phenotype. The transition from effector to anergic state was substantially faster in ST2-deficient perinates, whe

SUBMITTER: Tuncel J 

PROVIDER: S-EPMC6547863 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature