Transcriptomic response of Arabidopsis thaliana exposed to hydroxylated polychlorinated biphenyls (OH-PCBs).

ABSTRACT: Hydroxylated polychlorinated biphenyls (OH-PCBs) are toxic contaminants produced by biotic or abiotic transformation of PCBs. In this study, we have tested the toxicity of 2,5-dichlorobiphenyl (2,5-DCB) and three of its OH-derivatives, 2'-OH-, 3'-OH-, and 4'-OH-2,5-DCB toward the model plant, Arabidopsis thaliana. Toxicity tests showed that the parent 2,5-DCB (5 mg L^-1) had little effect on the plants, while all three OH-metabolites (5 mg L^-1) exhibited a significant toxicity, with 4'-OH-2,5-DCB being the most potent (inhibition concentration 50%-IC₅₀ in germination tests = 9.8 mg L^-1 for 2'-OH-2,5-DCB, 9.5 mg L^-1 for 3'-OH-2,5-DCB, and 4.8 mg L^-1 for 4'-OH-2,5-DCB). Whole-genome expression microarrays (Affymetrix) showed th

SUBMITTER: Subramanian S 

PROVIDER: S-EPMC6548195 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature