Extracellular Processing of Lysyl Oxidase-like 2 and Its Effect on Amine Oxidase Activity.

ABSTRACT: Overexpression of lysyl oxidase-like 2 (LOXL2) is associated with several hepatic and vascular fibrotic diseases and tumor progression in some aggressive cancers. Secreted LOXL2 promotes extracellular matrix cross-linking by catalyzing the oxidative deamination of peptidyl lysine. A great deal remains to be learned about the post-translational modifications of LOXL2, including whether such modifications modulate enzymatic and disease-promoting activities; such knowledge would inform the development of potential therapies. We discovered that upon secretion in cell culture, LOXL2 undergoes proteolytic processing of the first two of four scavenger receptor cysteine-rich domains at the N-terminus. A similar pattern of processing was also evident in tissue extracts from an invasive ductal carci

SUBMITTER: Okada K 

PROVIDER: S-EPMC6548334 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature