The prediction of early preeclampsia: Results from a longitudinal proteomics study.

ABSTRACT:

Objectives

To identify maternal plasma protein markers for early preeclampsia (delivery <34 weeks of gestation) and to determine whether the prediction performance is affected by disease severity and presence of placental lesions consistent with maternal vascular malperfusion (MVM) among cases.

Study design

This longitudinal case-control study included 90 patients with a normal pregnancy and 33 patients with early preeclampsia. Two to six maternal plasma samples were collected throughout gestation from each woman. The abundance of 1,125 proteins was measured using high-affinity aptamer-based proteomic assays, and data were modeled using linear mixed-effects models. After data transformation into multiples of the mean values for gestational age, parsimonious linear discrimina

SUBMITTER: Tarca AL 

PROVIDER: S-EPMC6548389 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature