T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function.

ABSTRACT: Innate lymphoid cells (ILCs) play an important role in regulating immune responses at mucosal surfaces. The transcription factor T-bet is crucial for the function of ILC1s and NCR⁺ ILC3s and constitutive deletion of T-bet prevents the development of these subsets. Lack of T-bet in the absence of an adaptive immune system causes microbiota-dependent colitis to occur due to aberrant ILC3 responses. Thus, T-bet expression in the innate immune system has been considered to dampen pathogenic immune responses. Here, we show that T-bet plays an unexpected role in negatively regulating innate type 2 responses, in the context of an otherwise intact immune system. Selective loss of T-bet in ILCs leads to the expansion and increased activity of ILC2s, which has a functionally important imp

SUBMITTER: Garrido-Mesa N 

PROVIDER: S-EPMC6548562 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature