Predicting Circulating CA125 Levels among Healthy Premenopausal Women.

ABSTRACT:

Background

Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women.

Methods

We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (≥35 U/mL) CA125 prediction models and externally validated an abridged model restricting to available predictors among 473 premenopausal women in the European Prospective Investigation into Cancer and Nutrition Study (EPIC).

Results

The final linear CA125 prediction model included age, race, tubal ligation, endometriosis,

SUBMITTER: Sasamoto N 

PROVIDER: S-EPMC6548604 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature