The relation of telomere length at midlife to subsequent 20-year depression trajectories among women.

ABSTRACT:

Background

Telomeres cap and protect DNA but shorten with each somatic cell division. Aging and environmental and lifestyle factors contribute to the speed of telomere attrition. Current evidence suggests a link between relative telomere length (RTL) and depression but the directionality of the relationship remains unclear. We prospectively examined associations between RTL and subsequent depressive symptom trajectories.

Methods

Among 8,801 women of the Nurses' Health Study, depressive symptoms were measured every 4 years from 1992 to 2012; group-based trajectories of symptoms were identified using latent class growth-curve analysis. Multinomial logistic models were used to relate midlife RTLs to the probabilities of assignment to subsequent depressive symptom trajectory gro

SUBMITTER: Gillis JC 

PROVIDER: S-EPMC6548605 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature