Functional and effective reorganization of the aging brain during unimanual and bimanual hand movements.

ABSTRACT: Motor performance decline observed during aging is linked to changes in brain structure and function, however, the precise neural reorganization associated with these changes remains largely unknown. We investigated the neurophysiological correlates of this reorganization by quantifying functional and effective brain network connectivity in elderly individuals (n = 11; mean age = 67.5 years), compared to young adults (n = 12; mean age = 23.7 years), while they performed visually-guided unimanual and bimanual handgrips inside the magnetoencephalography (MEG) scanner. Through a combination of principal component analysis and Granger causality, we observed age-related increases in functional and effective connectivity in whole-brain, task-related motor networks. Specifically, elderly individu

SUBMITTER: Lariviere S 

PROVIDER: S-EPMC6548623 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature