Novel Targeting to XCR1⁺ Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes.

ABSTRACT: Vaccination strategy that induce efficient antibody responses polytopically in most lymph nodes (LNs) against infections has not been established yet. Because donor-specific blood transfusion induces anti-donor class I MHC antibody production in splenectomized rats, we examined the mechanism and significance of this response. Among the donor blood components, T cells were the most efficient immunogens, inducing recipient T cell and B cell proliferative responses not only in the spleen, but also in the peripheral and gut LNs. Donor T cells soon migrated to the splenic T cell area and the LNs, with a temporary significant increase in recipient NK cells. XCR1⁺ resident dendritic cells (DCs), but not XCR1^- DCs, selectively phagocytosed donor class I MHC⁺ fragme

SUBMITTER: Kitazawa Y 

PROVIDER: S-EPMC6548820 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature