Downregulation of MHC Class I Expression by Influenza A and B Viruses.

ABSTRACT: Manipulation of the MHC-I presentation pathway, and thus limiting MHC-I cell surface expression, is used by many viruses to evade immune recognition. In particular, downregulation of MHC-I molecules at the cell surface can reduce the ability of CD8⁺ T cells to recognize viral peptides presented by MHC-I molecules and thereby delay viral clearance by CD8⁺ T cells. To date, MHC-I downregulation by influenza viruses has not been reported. Given that influenza virus infections are a global health concern and that CD8⁺ T cells play an important role in promoting influenza virus clearance and recovery from influenza disease, we investigated whether influenza A and B viruses (IAV, IBV) downregulated MHC-I as a novel mechanism to evade cellular immunity. Here, we s

SUBMITTER: Koutsakos M 

PROVIDER: S-EPMC6548845 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature