Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1.

ABSTRACT: RNA binding proteins, including IMP1/IGF2BP1, are essential regulators of intestinal development and cancer. Imp1 hypomorphic mice exhibit gastrointestinal growth defects, yet the specific role for IMP1 in colon epithelial repair is unclear. Our prior work revealed that intestinal epithelial cell-specific Imp1 deletion (Imp1^ΔIEC ) was associated with better regeneration in mice after irradiation. Here, we report increased IMP1 expression in patients with Crohn's disease and ulcerative colitis. We demonstrate that Imp1^ΔIEC mice exhibit enhanced recovery following dextran sodium sulfate (DSS)-mediated colonic injury. Imp1^ΔIEC mice exhibit Paneth cell

SUBMITTER: Chatterji P 

PROVIDER: S-EPMC6549032 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature