The association of genetic variants in FGFR2 with osteoporosis susceptibility in Chinese Han population.

ABSTRACT: Objective: The present study was conducted for exploring the influence of fibroblast growth factor 2 receptor (FGFR2) gene polymorphisms on osteoporosis occurrence risk in the Chinese population.Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was conducted for the genotyping of polymorphism in 145 osteoporosis patients and 123 controls. The status of Hardy-Weinberg equilibrium was detected in the control group. Genotype and allele frequency comparison of polymorphism between the two groups was performed by χ2 test, odds ratio (OR) with 95% confidence interval (95% CI) was used for the result expression about the association of FGFR2 polymorphisms with osteoporosis. Furthermore, the results were adjusted by clinical features via logistic regression ana

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6549083 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature